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Lamar Jackson and DeShaun Watson square off in primetime as Clemson hosts Louisville. The two players are battling for many things. It is a conference game and the winner will be the favorite to win the ACC. Given both teams are ranked in the top five, each squad also has their sights set on the College Football Playoff. Finally, both quarterbacks are in the running for arguably the most well-known award in all of sports, the Heisman Trophy. All odds listed are courtesy of OddsShark and are based on the Vegas data before the Louisville-Clemson game. Jackson entered the weekend as the favorite to win the award at -250 based on his stellar 25 touchdown start to the season. Watson is all the way down at +900 which puts him at fourth among the favorites. Watson has had a slow start to the season, but he still has time to move up the rankings if Clemson is in the running for the College Football Playoff. Heavy breaks down the favorites to win the award along with the Vegas odds. In addition to the top favorites, Leonard Fournette and Dalvin Cook are tied for eighth at +3300. Jake Browning is all the way down at 12th with +10,000 but will get a boost based on his performance against Stanford. Click the arrow to the right of the above image to see the latest Heisman Trophy odds and favorites. (Getty)