Both teams are coming off big Week 3 victories.
The Patriots, playing with rookie Jacoby Brissett under center, embarrassed the Houston Texans on Thursday Night Football, while the Bills got their first win of the season with a 33-18 shellacking of the Arizona Cardinals.
With the Pats already running away with the AFC East, and with Tom Brady set to return next week, this may be the Bills’ best chance to keep things interesting in the division.
Here’s everything you need to know to watch:
Bills vs. Patriots Week 4 Viewing Info
Date: Sunday, October 2, 2016
Start Time: 1 p.m. ET
TV Channel: CBS in certain markets. You can click here to see a map of what games will be shown in what cities
Announcers: Ian Eagle, Dan Fouts
Live Stream: NFL Sunday Ticket if the game is outside your market. You can click here for a complete rundown of all the live stream options
Line: Patriots (-6.5), per OddsShark
The best Week 4 NFL picks against the spread.Click here to read more