Gallery: 3/5
Denver Broncos
Opponent: at New Orleans Saints
Line: DEN (+2.5)
It's a game of strength vs. strength and weakness vs. weakness, as the Broncos boast the league's No. 1 defense (in terms of yards per play) and No. 26 offense, while the Saints boast the No. 3 offense and No. 31 defense. Usually I'll bet on the better quarterback in this kind of situation, but there are exceptions when he's up against a pass defense that is playing at a historically good level. The Broncos have held Cam Newton, Andrew Luck, Andy Dalton, Jameis Winston, Matt Ryan, Philip Rivers and Derek Carr (that's six players in the Top 17 of QBR plus last year's MVP) to 54.7 percent passing, 189.9 yards per game, 5.5 yards per attempt and a 6:8 TD:INT ratio in eight games, so they should be able to slow down Drew Brees--even in New Orleans--enough to win. (Getty)