New Orleans Saints
Opponent: at San Francisco 49ers
Line: NO (-3)
The Saints are a different team--in a bad way--on the road, and usually I like to stay away from them anytime they're away from the Superdome. Playing against San Francisco is an exception, though. The 'Niners have lost six in a row by an average margin of 17.17 points, they are last in the NFL in scoring defense and they're 24th in scoring offense. The Saints, meanwhile, fresh off a huge win over the Seahawks, have weapons all over the field on offense and are quietly playing a little better on defense. Even on the road, they should easily get the best of this matchup. (Getty)