Gallery: 2/7
Start: Jameis Winston, QB, Tampa Bay Buccaneers
Opponent: at Arizona Cardinals
A matchup at Arizona may lead owners to shy away from the talented second-year quarterback, but Jimmy Garoppolo--in his first NFL start with several starters, including future Hall of Fame tight end Rob Gronkowski, missing on offense--still managed 264 yards and a touchdown in the exact same spot in Week 1. Ultimately, Winston looked terrific in the opener (281 yards, four touchdowns) against a Falcons defense that was very stingy against QB's last year, he's an underdog in a game that is projected to be a potential shootout (over/under: 50), which means high volume, and he has a lot of playmakers at his disposal. Another Top-5 week may be difficult, but I expect Winston to again put up QB1 numbers in 12-team leagues. (Getty)