College Football Picks & Odds: Top 5 Best Bets Against the Spread Week 7

No. 2 Duke (+35) Over Louisville

Spread: Louisville by 35

Take the Points: Louisville has been able to put up points, but Vegas is underestimating Duke. Don't expect the Blue Devils to pull off the upset, but they will keep this one closer than 35 points. Duke has had an up and down season but does have a win against Notre Dame. Louisville has the potential to be in a letdown spot after a difficult loss to Clemson last time out. (Getty)