College Football Week 12 Odds: Oklahoma, LSU, Michigan, USC Betting Lines

Baker Mayfield and the Oklahoma Sooners face a major roadblock in their bid for the Big 12 with a visit to play the West Virginia Mountaineers this weekend.

Oklahoma is listed as the 2.5-point favorite with a 67 total at sportsbooks monitored by Oklahoma is 14-0 straight-up and 10-4 against the spread in their last 14 games versus the Big 12, according to the OddsShark College Football Database. West Virginia is 8-2 in their last 10 November games as the underdog.

The LSU Tigers are favored by 13.5 against the Florida Gators with a 38.5 total. Florida is 1-4 ATS in its last five games in Week 12, while LSU is 2-7 ATS in its last nine games in Week 12.

Having fallen from the ranks of the undefeated, the Clemson Tigers are the 22.5-point favorite against the Wake Forest Demon Deacons. Wake Forest is 3-7 ATS in its last 10 games in Week 12. Clemson is 10-0 SU and 7-3 ATS in its last 10 games after a loss.

The Michigan Wolverines, also coming off their first loss, are the 24-point favorite against the Indiana Hoosiers. Indiana is 1-6 ATS in its last seven games in Week 12. Michigan is 6-2 ATS in its last eight games after a loss.

The Ohio State Buckeyes are favored by 22.5 points on the road against the Michigan State Spartans on the Vegas odds, with a 54 total. Ohio State is 15-4 ATS in its last 19 games after losing the previous game in a matchup. Michigan State is 1-7 SU and 2-6 ATS in its last eight games.

The TCU Horned Frogs are the 4.5-point favorite against the Oklahoma State Cowboys with a 70.5 total. Oklahoma State is 5-2 ATS in its last seven road games, while TCU is 0-5 ATS in its last five home games.

The Notre Dame Fighting Irish are favored by one point against the Virginia Tech Hokies, with a 55 total. Virginia Tech is 2-11 ATS in its last 13 games on the road against teams with losing records. Notre Dame is 3-8 ATS in its last 11 games in November.

The Colorado Buffaloes are also favored by 4.5 against the Washington State Cougars with a 60 total. Washington State is 12-4 ATS in its last 16 games against the Pac-12. Colorado is 10-1 ATS in its last 11 games.

And the USC Trojans are favored by 13.5 on the Vegas lines in their rivalry game against the UCLA Bruins. Southern Cal is 2-5 SU and 1-6 ATS in its last seven games on the road after winning their most recent road game, while UCLA is 8-1 SU and ATS in its last nine games in Week 12.

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