Start: Sterling Shepard, WR, New York Giants
Opponent: New Orleans Saints
As a 4.5-point home favorite in a game with a huge over/under of 53, the G-Men boast one of the highest projected team totals of Week 2 at 28.75. In Week 1, Shepard and Victor Cruz were each targeted four times, each caught a touchdown and were each on the field for the majority of the game (Shepard 53 of 56 offensive snaps, Cruz 50 of 56), as the Giants mostly used 3-WR sets. While that makes it difficult to know who to trust, Shepard looked great in his NFL debut, and even with Cruz involved, there will be enough passing-game success against the Saints' colander-like secondary that Shepard will have some big plays. (Getty)