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NFL Week 16 Predictions: Best Picks Against the Spread

Tampa Bay Buccaneers


Opponent: at New Orleans Saints


Line: TB (+3)


There's always a lot of talk about Drew Brees' stark home/away splits, but the Saints are still just 3-5 at the Superdome this year. The Bucs, on the other hand, are 5-3 on the road and nearly beat the Dallas Cowboys--co-owners of the best record in football--at Jerry World on Sunday night. Ultimately, the Bucs are the better team--as they proved two weeks ago when they beat the Saints--and they're getting three points, so this is a tough one to pass up. (Getty)

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NFL Week 16 odds, predictions and the best picks against the spread.