Start: Alex Collins, Seattle Seahawks
Opponent: at San Francisco 49ers
This is contingent on the status of Thomas Rawls, who sounds highly questionable after injuring his shoulder last week. If Rawls does sit, Collins, who hasn't done much this season but looked good in limited action last week, will be staring at a bell-cow-type role against a 49ers defense that has been punished by opposing running backs all year long. (Getty)