Gallery: 3/6
Chicago Bears
Opponent: at Indianapolis Colts
Line: CHI (+4.5)
Teams typically get a bye week after having to play in London, but the Colts get no such luxury. They at least get to play at home, but don't be surprised if they come out a bit sluggish in this one. And while the Bears (1-3) don't exactly serve as the most formidable opponent, the offense is averaging 399.0 yards per game and 6.1 yards per play in Brian Hoyer's two starts and should be able to move the ball efficiently against a Colts defense that ranks 30th in Football Outsiders' efficiency ratings. Throw in the fact that Chicago is getting 4.5 points, and this is a strong bet to make. (Getty)
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NFL Week 5 Predictions: Best Picks Against the Spread