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NFL Week 16 Predictions: Best Picks Against the Spread

Tennessee Titans


Opponent: at Jacksonville Jaguars


Line: TEN (-4.5)


The Titans have reeled off three wins in a row, including impressive victories over potential playoff squads in the Broncos and the Chiefs. The Jaguars, meanwhile, have dropped nine consecutive games, have the fifth worst point differential (-99) in the NFL and just fired their head coach. The Titans beat the Jags by 14 when they met in early November, and the difference between them is now even greater than it was back then. Even on the road, the Titans should win this by at least a touchdown. (Getty)

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NFL Week 16 odds, predictions and the best picks against the spread.