The Panthers defeated the Cardinals on Wildcard Weekend and earned a trip up to Seattle to take on the defending champion Seahawks in the Divisional round.
The Panthers earned the NFC South title and finished the No. 4 seed with a 7-8-1 record. The Seahawks won the West and earned the No. 1 seed with a 12-4 record.
This will be the first playoff meeting between the two teams since the 2005 NFC Championship game.
Kickoff is set for 8:15 p.m. Eastern on Sunday. Fox will have the broadcast.
Seattle opened up as a 10-point favorite at Pinnacle Sports.
The other NFC Divisional game will feature the Cowboys taking on the Packers. That game will be at 1:05 p.m. Eastern on Sunday, also broadcasted on Fox.
The AFC will feature the Ravens playing the Patriots on Saturday at 4:30 p.m. Eastern and the Colts taking on the Broncos on Sunday at 4:40 p.m. Eastern.
Correction: A previous version of this post incorrectly reported that the Panthers were playing the Green Bay Packers in the divisional round.