Serie A Matchday 4 – Weekend Preview and Predictions – Sept. 11-14

Gennaro Gattuso
Getty
Gennaro Gattuso leads Lazio to a perfect start but will be tested on Saturday when AC Milan come to visit the Stadio Olimpico. (Photo by Timothy Rogers/Getty Images)

Three teams head into the fourth round of Serie A still perfect, while three others remain without a single point. The early weeks have already delivered a managerial change, promoted sides punching above their weight, and several tight, high-stakes contests that have kept the table tightly packed and the narrative lively.

Friday, Sept. 11

Venezia vs. Fiorentina — 20:45 CET / 2:45 PM ET

Both sides are still searching for their first points. Fiorentina’s early chaos has already cost a manager, while Venezia have shown fight without reward. The home side’s urgency and the visitors’ defensive fragility point to a first win for the Lagunari.

Prediction: Venezia 2-1 Fiorentina

Saturday, Sept. 12

Genoa vs. Frosinone — 15:00 CET / 9:00 AM ET

Genoa sit at the bottom alongside Venezia and Fiorentina without a single point under coach Daniele De Rossi, coming off a heavy 1-4 defeat to Como. Frosinone, by contrast, have settled into life back in the top flight remarkably well under Massimiliano Alvini, climbing to seventh with six points after a 3-0 win at Fiorentina and a 3-2 win over Venezia. The visitors’ current form makes them clear favorites to leave Marassi with maximum points.

Prediction: Genoa 0-2 Frosinone

Lazio vs. AC Milan — 18:00 CET / 12:00 PM ET

Lazio are perfect through three rounds under Gennaro Gattuso, winning all three matches by a single goal — a genuinely remarkable feat given the backdrop, with the club’s own fans boycotting home matches at the Olimpico in protest against president Claudio Lotito. Milan, meanwhile, remain unbeaten but not flawless under new manager Ruben Amorim, having opened with wins over Torino and Venezia before being held to a 1-1 draw at Juventus last weekend. Milan’s slightly greater quality on the road should be enough to edge a competitive contest in Rome.

Prediction: Lazio 1-2 AC Milan

Atalanta vs. Cagliari — 20:45 CET / 2:45 PM ET

Atalanta will look to bounce back from a late defeat in the capital. Home form under Maurizio Sarri should prove decisive against a solid but limited Cagliari side.

Prediction: Atalanta 2-0 Cagliari

Juventus
GettyJuventus’ Italian defender #04 Federico Gatti celebrates scoring his team’s first goal during the Italian Serie A football match between Juventus and AC Milan at the Allianz Stadium in Turin on September 6, 2026. (Photo by Isabella BONOTTO / AFP via Getty Images)

Sunday, Sept. 13

Lecce vs. Monza — 15:00 CET / 9:00 AM ET

A meeting of two sides still finding consistency. Neither has shown enough to dominate, pointing toward a shared result.

Prediction: Lecce 1-1 Monza

Napoli vs. Bologna — 18:00 CET / 12:00 PM ET

Napoli’s home advantage and greater depth should see them past a well-organized Bologna, though the visitors are capable of making it uncomfortable.

Prediction: Napoli 2-1 Bologna

Sassuolo vs. Juventus — 20:45 CET / 2:45 PM ET

Juventus remain unbeaten but are dealing with injuries and a lack of cutting edge. Sassuolo have been competitive at home and look capable of frustrating the visitors into a share of the points.

Prediction: Sassuolo 1-1 Juventus

Monday, Sept. 14

Como vs. Parma — 18:30 CET / 12:30 PM ET

Como return to Serie A action still buzzing from their historic Champions League debut win over RB Leipzig and sit unbeaten in the league after strong results against Napoli and Genoa. Cesc Fàbregas has a nearly full squad (only long-term absentee Jayden Addai is out) and can rotate options such as Moise Kean, Anastasios Douvikas, Nico Paz, Martin Baturina and Assane Diao. Parma have just one point from three games, remain goal-shy on the road, and are missing or doubtful for Hans Nicolussi Caviglia, Adrián Bernabé and others. Como’s home form and superior quality should prove decisive.
Prediction: Como 3-1 Parma

Torino vs. AS Roma — 18:30 CET / 12:30 PM ET

Roma head to Turin top of the table (or joint-top) after three straight Serie A wins and a hard-fought Champions League point in Istanbul. Gian Piero Gasperini’s side have been free-scoring, with Donyell Malen among the early standouts, though Manu Koné is a doubt and rotation is possible. Torino claimed their first league win under Ignazio Abate by coming from behind against Fiorentina, but they have conceded in every match so far and face a stern test against Roma’s attacking depth. History heavily favours the visitors on this ground.
Prediction: Torino 0-2 Roma

Inter vs. Udinese — 20:45 CET / 2:45 PM ET

Inter look to rebound from their Champions League defeat at Real Madrid and extend their perfect domestic start (three wins, eight goals scored). Cristian Chivu should have most of his key players available, including Lautaro Martínez (who has an excellent record against Udinese) and a returning Federico Dimarco; Djed Spence remains out. Udinese suffered their first loss of the season to Lazio and are missing several players (including recent casualties Jakub Piotrowski and Oumar Solet, plus longer-term absentees). Inter’s home strength and greater quality make them clear favourites to close the round with another victory.
Prediction: Inter 2-0 Udinese

In the U.S., the games can be seen on CBS/Paramount+ (English) and Telemundo/Peacock (Spanish). In the U.K., games can be seen on DAZN, with one game on TNT Sports (Sassuolo vs. Juventus). In Canada, games are on DAZN, TLN, and FuboTV.

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Serie A Matchday 4 – Weekend Preview and Predictions – Sept. 11-14

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