Patriots vs. Bills: Odds, Point Spread & Over-Under

Dion Lewis was the feature back for New England in Week 1. Getty)

Dion Lewis was the feature back for New England in Week 1. (Getty)

Editor’s note: The odds below are courtesy of Heavy’s partners at OddsShark. Click here for more odds and betting info at

Rex Ryan doesn’t have to wait long into his tenure as Bills coach to get a shot at division king Tom Brady and the New England Patriots. The teams meet in Week 2 on Sunday.

Ryan was 4-9 against the Patriots in his six seasons with the Jets, but always gave Bill Belichick and Brady fits.

Both teams are coming off impressive Week 1 wins; the Patriots defeated the Steelers and the Bills beat the Colts.

Here’s what you need to know about the game:

Patriots-Bills Point Spread

Patriots … Pickem

Bills … Pickem

The Patriots are 21-2 in their last 23 games against the Bills.

The Patriots are 8-2-1 against the spread in their last 10 trips to Buffalo

The Bills are 5-1 in their last six home games.

The Bills are 5-2 against the spread in their last seven games.

Patriots-Bills Over-Under

Over-Under … 45

The total has gone over eight of the last 10 meetings

The total has gone under in Buffalo’s last five home games.

The total has gone under in seven of New England’s last 10 games, and eight of Buffalo’s last nine games.

Patriots-Bills Money Line

Patriots … -110

Bills … -110

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