Knox hit the ground running in his return to practice after being designated for return from injured reserve earlier Wednesday. His full participation suggests Knox has a chance to return as soon as Sunday's game in Kansas City, though he would first have to be officially activated from IR no later than Saturday at 4 p.m. ET. Rookie first-round pick Dalton Kincaid has excelled in Knox's absence, and Kincaid will likely remain the top pass catcher among Buffalo's tight ends whenever Knox is cleared for game action.
Knox missed five games (Weeks 8-12) and is now ready to practice after a Week 13 bye. Coach Sean McDermott isn't sure if the tight end will be ready for Sunday's game against the Chiefs, per Katherine Fitzgerald of The Buffalo News, but it would at least seem Knox stands a good chance to play Week 15 or 16. Rookie tight end Dalton Kincaid emerged as a reliable fantasy starter in Knox's absence the past month and a half, though No. 3 wide receiver was actually the biggest winner in terms of added playing time, as the Bills pivoted to far fewer multi-TE formation and more three-wide looks. Many have noted that WR Stefon Diggs has far better numbers with Knox in the lineup this year, though it's hard to say if that's really about the tight end or more a product of variance/matchups.
Knox, who remains on IR, last suited up in Week 7, but it's possible that he could return to the mix as soon as the Bills' Dec. 10 contest against the Chiefs. While that's hardly a lock to happen, it does appear as though the tight end will be back before the end of the season. In the meantime, Dalton Kincaid will remain the team's top TE option.