Deommodore Lenoir: Everything you need to know

Lenoir finished the 2025 regular season with 61 tackles (39 solo) and two interceptions across 17 starts. Lenoir turned in another strong campaign as a shutdown coverage corner for the 49ers, but his IDP numbers took a slight dip in 2025. The 61 tackles registered as his lowest total in the four full seasons he has been a starter in the pros (averaged 82.7 last three years). The 25-year-old was rewarded with a lucrative five-year contract extension this past offseason, so expect Lenoir to continue operating as San Francisco's CB1 in 2026.

Lenoir posted seven tackles (four solo) and two pass defenses (including an interception) during the 49ers' 41-22 win over the Cardinals on Sunday. Lenoir was managing a calf injury during Week 11 prep but was cleared to play in Sunday's NFC West tilt. It didn't appear to bother him all that much, as he played 66 of 79 defensive snaps (83.5 percent) while finishing in a three-way tie for the most tackles on the 49ers behind Curtis Robinson (11) and Dee Winters (10). Lenoir also picked off Jacoby Brissett late in the third quarter, and the former was able to weave his way through would-be tacklers for a 64-yard return to set the 49ers offense up in the red zone, leading to a four-yard touchdown pass from Brock Purdy to George Kittle five plays later. Lenoir is up to 40 tackles (28 solo) and five pass defenses (two interceptions) through 11 regular-season games.

Lenoir (calf) is active for Sunday's Week 11 matchup against Arizona, Eric Branch of the San Francisco Chronicle reports. Lenoir dealt with a calf issue at the end of the week and was deemed questionable on Friday's final injury report. The Oregon product is ultimately going to play, which is a big development for the 49ers' secondary. Lenoir has logged every defensive snap for San Francisco each of the past seven weeks.