James Cook: Everything you need to know

Cook rushed 24 times for 117 yards and brought in two of three targets for 24 yards in the Bills' 33-30 divisional-round overtime loss to the Broncos on Saturday. He also lost a fumble. Cook put together an impressive day on the ground against an elite defense, finishing with his 10th 100-yard rushing performance since the start of the regular season and bouncing back in noteworthy fashion from his 46-yard effort versus the Jaguars in Sunday's wild-card victory. Cook's second-quarter lost fumble had a significant impact, however, as it came at the Broncos' 30-yard line and eventually led to a Denver touchdown. The disappointing team outcome aside, Cook's productive day Saturday was a fitting cap to a career-best regular season, one where he won the NFL rushing yardage title with 1,621 yards while averaging 5.2 yards per carry, scored 12 rushing touchdowns, and generated a 33-291-2 line on 40 targets while committing six fumbles, losing three, across 17 games.

Cook carried the ball 15 times for 46 yards and caught two of three targets for five yards in the Bills' 27-24 win over the Jaguars during the wild-card round Sunday. After amassing a career-high 1,621 yards during the regular season to secure his first career rushing crown, Cook had trouble finding room to roam against an elite Jags run defense, with his longest gain going for just 11 yards. Not counting a Week 18 contest in which he made only a cameo appearance, it was the first time Cook had been held below 50 yards since Week 11. The Bills won't know who they're playing next until after the weekend's games are over, but Cook is likely to face another tough opponent next weekend, with the Broncos and Texans among their potential divisional-round matchups.

Cook rushed twice for 15 yards and wasn't targeted in Sunday's 35-8 win over the Jets. He finished the regular season with 309 carries for 1,621 yards and 12 touchdowns while adding 33 catches for 291 yards and two touchdowns on 40 targets. Cook notched carries of 10 yards and five yards on the game's first two plays before letting Ray Davis and Ty Johnson split Buffalo's backfield workload the rest of the way. Despite Cook's limited workload in the regular-season finale, he'll finish as the league leader in rushing yards unless Derrick Henry gains at least 153 rushing yards on Sunday Night Football. The Bills earned the No. 6 seed in the AFC and will go on the road against the Jaguars in the wild-card round.