Upton Stout: Everything you need to know

Stout finished with 82 tackles (43 solo), one sack and one forced fumble across 16 regular-season games in 2025. Stout was drafted in the third round of the 2025 NFL Draft and was inserted as the 49ers' starting slot corner right out of the gates. The 23-year-old suffered from the occasional blown coverage, but the overall results were positive given the prominent role he was asked to fill as a rookie. The 82 combined tackles stand out from a fantasy perspective, especially considering he only saw the field in nickel or lighter formations. Stout should only improve with experience now that he solidified himself as the team's starting slot cornerback for the 2026 season.

Stout (concussion) is active for Saturday night's game against the Seahawks, Briana Jeannel of the 49ers' official site reports. Stout was able to clear the NFL's five-step concussion protocol in time for Saturday's divisional clash. The third-round rookie will have a task ahead of him, as he will likely face matchups with 2025 receiving yards leader Jaxon Smith-Njigba as well as Cooper Kupp and Rashid Shaheed.

Stout (concussion) is questionable to play against the Seahawks on Saturday. Stout suffered a concussion against the Bears on Sunday and logged an LP/LP/FP practice progression this week. Despite Friday's full session, he's been tabbed questionable for Week 18, which may mean he has yet to clear the NFL's five-step concussion protocol. If Stout is able to get clearance to play, including from an independent neurologist, he'll likely take on his usual role as San Francisco's starting slot cornerback for a battle with Seattle that will determine the No. 1 NFC playoff seed.